Gene Cluster: ALS2

Organism: Homo sapiens

amyotrophic lateral sclerosis 2 (juvenile)

Map: 2q33.1

GO:0001662 behavioral fear response
GO:0001726 ruffle
GO:0001881 receptor recycling
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005087 Ran guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005813 centrosome
GO:0005829 cytosol
GO:0006979 response to oxidative stress
GO:0007032 endosome organization
GO:0007528 neuromuscular junction development
GO:0007626 locomotory behavior
GO:0008104 protein localization
GO:0014069 postsynaptic density
GO:0016050 vesicle organization
GO:0016197 endosome transport
GO:0017112 Rab guanyl-nucleotide exchange factor activity
GO:0017137 Rab GTPase binding
GO:0030027 lamellipodium
GO:0030676 Rac guanyl-nucleotide exchange factor activity
GO:0032313 regulation of Rab GTPase activity
GO:0032855 positive regulation of Rac GTPase activity
GO:0035022 positive regulation of Rac protein signal transduction
GO:0035023 regulation of Rho protein signal transduction
GO:0035249 synaptic transmission, glutamatergic
GO:0042598 vesicular fraction
GO:0042803 protein homodimerization activity
GO:0043197 dendritic spine
GO:0043234 protein complex
GO:0043539 protein serine/threonine kinase activator activity
GO:0045860 positive regulation of protein kinase activity
GO:0048812 neurite morphogenesis
GO:0051036 regulation of endosome size

Reference Sequence: NM_020919.2

6470bp CDS 200..5173

ALS2 (5:5'UTR, C:CDS, 3:3'UTR, N:Unknown)

Human

Chimpanzee