Gene Cluster: MTHFD1

Organism: Homo sapiens

Synonymous: MTHFC|MTHFD

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase

Link to Entrez Gene

Map: 14q24

GO:0000105 histidine biosynthetic process
GO:0000166 nucleotide binding
GO:0004329 formate-tetrahydrofolate ligase activity
GO:0004477 methenyltetrahydrofolate cyclohydrolase activity
GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0006164 purine nucleotide biosynthetic process
GO:0006548 histidine catabolic process
GO:0006730 one-carbon compound metabolic process
GO:0008652 amino acid biosynthetic process
GO:0009086 methionine biosynthetic process
GO:0009396 folic acid and derivative biosynthetic process
GO:0016155 formyltetrahydrofolate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016787 hydrolase activity
GO:0016874 ligase activity
GO:0055114 oxidation reduction

Reference Sequence: NM_005956.2

3110bp CDS 54..2861

Homologous cDNA sequence in the JCRB Genebank

MTHFD1 (5:5'UTR, C:CDS, 3:3'UTR, N:Unknown)

Human

Chimpanzee