Gene Cluster: SMAD4

Organism: Homo sapiens

Synonymous: DPC4|JIP|MADH4

SMAD family member 4

Link to Entrez Gene

Map: 18q21.1

GO:0001658 ureteric bud branching
GO:0001666 response to hypoxia
GO:0001702 gastrulation with mouth forming second
GO:0001822 kidney development
GO:0003700 transcription factor activity
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006350 transcription
GO:0007183 SMAD protein complex assembly
GO:0008285 negative regulation of cell proliferation
GO:0009952 anterior/posterior pattern formation
GO:0016563 transcription activator activity
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0030308 negative regulation of cell growth
GO:0030509 BMP signaling pathway
GO:0032909 regulation of transforming growth factor-beta2 production
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0045892 negative regulation of transcription, DNA-dependent
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046332 SMAD binding
GO:0051098 regulation of binding

Reference Sequence: NM_005359.3

3220bp CDS 234..1892

Homologous cDNA sequence in the JCRB Genebank

SMAD4 (5:5'UTR, C:CDS, 3:3'UTR, N:Unknown)

Human

Chimpanzee