Gene Cluster: APP

Organism: Homo sapiens

Synonymous: AAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN2

amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)

Link to Entrez Gene

Map: 21q21.2|21q21.3

GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005506 iron ion binding
GO:0005507 copper ion binding
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral to plasma membrane
GO:0005905 coated pit
GO:0006878 cellular copper ion homeostasis
GO:0006897 endocytosis
GO:0006915 apoptosis
GO:0007155 cell adhesion
GO:0007219 Notch signaling pathway
GO:0008201 heparin binding
GO:0008270 zinc ion binding
GO:0009986 cell surface
GO:0031093 platelet alpha granule lumen
GO:0033130 acetylcholine receptor binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0050905 neuromuscular process

Reference Sequence: NM_000484.2

3641bp CDS 195..2507

Homologous cDNA sequence in the JCRB Genebank

APP (5:5'UTR, C:CDS, 3:3'UTR, N:Unknown)

Human

Chimpanzee