Gene Cluster: APEX1

Organism: Homo sapiens

Synonymous: APE|APE1|APEN|APEX|APX|HAP1|REF-1|REF1

APEX nuclease (multifunctional DNA repair enzyme) 1

Map: 14q11.2-q12

GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004520 endodeoxyribonuclease activity
GO:0004523 ribonuclease H activity
GO:0004528 phosphodiesterase I activity
GO:0004844 uracil DNA N-glycosylase activity
GO:0005515 protein binding
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005813 centrosome
GO:0005840 ribosome
GO:0006284 base-excision repair
GO:0006366 transcription from RNA polymerase II promoter
GO:0008408 3`-5` exonuclease activity
GO:0016491 oxidoreductase activity
GO:0016829 lyase activity
GO:0048471 perinuclear region of cytoplasm
GO:0051101 regulation of DNA binding

Reference Sequence: NM_001641.2

1574bp CDS 333..1289

APEX1 (5:5'UTR, C:CDS, 3:3'UTR, N:Unknown)

Chimpanzee