Gene Cluster: GCLC

Organism: Homo sapiens

Synonymous: GCS|GLCL|GLCLC

glutamate-cysteine ligase, catalytic subunit

Link to Entrez Gene

Map: 6p12

GO:0000287 magnesium ion binding
GO:0004357 glutamate-cysteine ligase activity
GO:0005829 cytosol
GO:0006534 cysteine metabolic process
GO:0006536 glutamate metabolic process
GO:0006750 glutathione biosynthetic process
GO:0006916 anti-apoptosis
GO:0006979 response to oxidative stress
GO:0009408 response to heat
GO:0009410 response to xenobiotic stimulus
GO:0009725 response to hormone stimulus
GO:0016481 negative regulation of transcription
GO:0016595 glutamate binding
GO:0016874 ligase activity
GO:0017109 glutamate-cysteine ligase complex
GO:0019852 L-ascorbic acid metabolic process
GO:0031397 negative regulation of protein ubiquitination
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043531 ADP binding
GO:0045454 cell redox homeostasis
GO:0046685 response to arsenic
GO:0046982 protein heterodimerization activity
GO:0050662 coenzyme binding
GO:0050880 regulation of blood vessel size
GO:0051900 regulation of mitochondrial depolarization

Reference Sequence: NM_001498.2

3717bp CDS 389..2302

Homologous cDNA sequence in the JCRB Genebank

GCLC (5:5'UTR, C:CDS, 3:3'UTR, N:Unknown)

Chimpanzee