Gene Cluster: TNFRSF10B

Organism: Homo sapiens

Synonymous: CD262|DR5|KILLER|KILLER/DR5|TRAIL-R2|TRAILR2|TRICK2|TRICK2A|TRICK2B|TRICKB|ZTNFR9

tumor necrosis factor receptor superfamily, member 10b

Link to Entrez Gene

Map: 8p22-p21

GO:0004872 receptor activity
GO:0005515 protein binding
GO:0005886 plasma membrane
GO:0006919 caspase activation
GO:0007165 signal transduction
GO:0007166 cell surface receptor linked signal transduction
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0008625 induction of apoptosis via death domain receptors
GO:0008633 activation of pro-apoptotic gene products
GO:0008656 caspase activator activity
GO:0016021 integral to membrane
GO:0042981 regulation of apoptosis
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0045569 TRAIL binding

Reference Sequence: NM_003842.3

4160bp CDS 286..1608

Homologous cDNA sequence in the JCRB Genebank

TNFRSF10B (5:5'UTR, C:CDS, 3:3'UTR, N:Unknown)

Human

Chimpanzee