Gene Cluster: TSC2

Organism: Homo sapiens

Synonymous: FLJ43106|LAM|TSC4

tuberous sclerosis 2

Link to Entrez Gene

Map: 16p13.3

GO:0001843 neural tube closure
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0005622 intracellular
GO:0005624 membrane fraction
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006469 negative regulation of protein kinase activity
GO:0006606 protein import into nucleus
GO:0007507 heart development
GO:0008104 protein localization
GO:0008285 negative regulation of cell proliferation
GO:0014067 negative regulation of phosphoinositide 3-kinase cascade
GO:0016020 membrane
GO:0030100 regulation of endocytosis
GO:0033596 TSC1-TSC2 complex
GO:0042803 protein homodimerization activity
GO:0043547 positive regulation of GTPase activity
GO:0045786 negative regulation of cell cycle
GO:0046626 regulation of insulin receptor signaling pathway
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0050918 positive chemotaxis
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051898 negative regulation of protein kinase B signaling cascade

Reference Sequence: NM_000548.2

5543bp CDS 19..5442

Homologous cDNA sequence in the JCRB Genebank

TSC2 (5:5'UTR, C:CDS, 3:3'UTR, N:Unknown)

Chimpanzee