Gene Cluster: TLR4

Organism: Homo sapiens

Synonymous: CD284|TOLL|hToll

toll-like receptor 4

Link to Entrez Gene

Map: 9q32-q33

GO:0001530 lipopolysaccharide binding
GO:0004888 transmembrane receptor activity
GO:0005515 protein binding
GO:0005886 plasma membrane
GO:0005887 integral to plasma membrane
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0009617 response to bacterium
GO:0016046 detection of fungus
GO:0042088 T-helper 1 type immune response
GO:0042116 macrophage activation
GO:0042535 positive regulation of tumor necrosis factor biosynthetic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0045084 positive regulation of interleukin-12 biosynthetic process
GO:0045087 innate immune response
GO:0045416 positive regulation of interleukin-8 biosynthetic process
GO:0045671 negative regulation of osteoclast differentiation
GO:0046330 positive regulation of JNK cascade
GO:0046696 lipopolysaccharide receptor complex
GO:0048471 perinuclear region of cytoplasm

Reference Sequence: NM_138554.2

5503bp CDS 142..2661

Homologous cDNA sequence in the JCRB Genebank

TLR4 (5:5'UTR, C:CDS, 3:3'UTR, N:Unknown)

Chimpanzee