Gene Cluster: PTPN11

Organism: Homo sapiens

Synonymous: BPTP3|CFC|MGC14433|NS1|PTP-1D|PTP2C|SH-PTP2|SH-PTP3|SHP2

protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1)

Map: 12q24

GO:0000077 DNA damage checkpoint
GO:0000187 activation of MAPK activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006470 protein amino acid dephosphorylation
GO:0006629 lipid metabolic process
GO:0006641 triacylglycerol metabolic process
GO:0007409 axonogenesis
GO:0007605 sensory perception of sound
GO:0009755 hormone-mediated signaling
GO:0009967 positive regulation of signal transduction
GO:0016787 hydrolase activity
GO:0035265 organ growth
GO:0040014 regulation of multicellular organism growth
GO:0042445 hormone metabolic process
GO:0042593 glucose homeostasis
GO:0046676 negative regulation of insulin secretion
GO:0046825 regulation of protein export from nucleus
GO:0046887 positive regulation of hormone secretion
GO:0048011 nerve growth factor receptor signaling pathway
GO:0048609 reproductive process in a multicellular organism
GO:0051428 peptide hormone receptor binding
GO:0051463 negative regulation of cortisol secretion
GO:0060125 negative regulation of growth hormone secretion

Reference Sequence: NM_002834.3

6300bp CDS 381..2162

Homologous cDNA sequence in the JCRB Genebank

PTPN11 (5:5'UTR, C:CDS, 3:3'UTR, N:Unknown)

Human

Chimpanzee