Gene Cluster: PSEN1

Organism: Homo sapiens

Synonymous: AD3|FAD|PS1|S182

presenilin 1 (Alzheimer disease 3)

Link to Entrez Gene

Map: 14q24.3

GO:0000139 Golgi membrane
GO:0000776 kinetochore
GO:0001568 blood vessel development
GO:0001708 cell fate specification
GO:0001756 somitogenesis
GO:0001764 neuron migration
GO:0001933 negative regulation of protein amino acid phosphorylation
GO:0001947 heart looping
GO:0002244 hemopoietic progenitor cell differentiation
GO:0002286 T cell activation during immune response
GO:0002573 myeloid leukocyte differentiation
GO:0004175 endopeptidase activity
GO:0005622 intracellular
GO:0005624 membrane fraction
GO:0005634 nucleus
GO:0005639 integral to nuclear inner membrane
GO:0005640 nuclear outer membrane
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral to plasma membrane
GO:0006486 protein amino acid glycosylation
GO:0006509 membrane protein ectodomain proteolysis
GO:0006916 anti-apoptosis
GO:0007059 chromosome segregation
GO:0007176 regulation of epidermal growth factor receptor activity
GO:0007220 Notch receptor processing
GO:0007242 intracellular signaling cascade
GO:0007507 heart development
GO:0007613 memory
GO:0008013 beta-catenin binding
GO:0008233 peptidase activity
GO:0009790 embryonic development
GO:0009791 post-embryonic development
GO:0009986 cell surface
GO:0016337 cell-cell adhesion
GO:0016485 protein processing
GO:0021904 dorsoventral neural tube patterning
GO:0030326 embryonic limb morphogenesis
GO:0030424 axon
GO:0030425 dendrite
GO:0030900 forebrain development
GO:0031410 cytoplasmic vesicle
GO:0035253 ciliary rootlet
GO:0040011 locomotion
GO:0042325 regulation of phosphorylation
GO:0042640 anagen
GO:0042987 amyloid precursor protein catabolic process
GO:0043025 cell soma
GO:0043065 positive regulation of apoptosis
GO:0043085 positive regulation of catalytic activity
GO:0045860 positive regulation of protein kinase activity
GO:0048167 regulation of synaptic plasticity
GO:0048538 thymus development
GO:0048854 brain morphogenesis
GO:0050435 beta-amyloid metabolic process
GO:0050820 positive regulation of coagulation
GO:0050852 T cell receptor signaling pathway
GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis

Reference Sequence: NM_000021.2

2763bp CDS 249..1652

Homologous cDNA sequence in the JCRB Genebank

PSEN1 (5:5'UTR, C:CDS, 3:3'UTR, N:Unknown)

Chimpanzee