Gene Cluster: NPR1

Organism: Homo sapiens

Synonymous: ANPRA|ANPa|GUC2A|GUCY2A|NPRA

natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)

Link to Entrez Gene

Map: 1q21-q22

GO:0004383 guanylate cyclase activity
GO:0004713 protein tyrosine kinase activity
GO:0004872 receptor activity
GO:0005524 ATP binding
GO:0005887 integral to plasma membrane
GO:0006182 cGMP biosynthetic process
GO:0006468 protein amino acid phosphorylation
GO:0007166 cell surface receptor linked signal transduction
GO:0007242 intracellular signaling cascade
GO:0008217 regulation of blood pressure
GO:0008528 peptide receptor activity, G-protein coupled
GO:0016020 membrane
GO:0016525 negative regulation of angiogenesis
GO:0030146 diuresis
GO:0030147 natriuresis
GO:0030308 negative regulation of cell growth
GO:0031404 chloride ion binding
GO:0042312 regulation of vasodilation
GO:0042562 hormone binding
GO:0043114 regulation of vascular permeability

Reference Sequence: NM_000906.2

4246bp CDS 471..3656

Homologous cDNA sequence in the JCRB Genebank

NPR1 (5:5'UTR, C:CDS, 3:3'UTR, N:Unknown)

Chimpanzee