Gene Cluster: MAP3K5

Organism: Homo sapiens

Synonymous: ASK1|MAPKKK5|MEKK5

mitogen-activated protein kinase kinase kinase 5

Link to Entrez Gene

Map: 6q22.33

GO:0000165 MAPKKK cascade
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005524 ATP binding
GO:0006468 protein amino acid phosphorylation
GO:0006915 apoptosis
GO:0007257 activation of JNK activity
GO:0008624 induction of apoptosis by extracellular signals
GO:0008656 caspase activator activity
GO:0016740 transferase activity
GO:0042803 protein homodimerization activity
GO:0044419 interspecies interaction between organisms

Reference Sequence: NM_005923.3

5215bp CDS 362..4486

Homologous cDNA sequence in the JCRB Genebank

MAP3K5 (5:5'UTR, C:CDS, 3:3'UTR, N:Unknown)

Human

Chimpanzee