Gene Cluster: HIF1A

Organism: Homo sapiens

Synonymous: HIF-1alpha|HIF1-ALPHA|MOP1|PASD8

hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Link to Entrez Gene

Map: 14q21-q24

GO:0001666 response to hypoxia
GO:0001755 neural crest cell migration
GO:0001837 epithelial to mesenchymal transition
GO:0001892 embryonic placenta development
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001947 heart looping
GO:0002248 connective tissue replacement during inflammatory response
GO:0003705 RNA polymerase II transcription factor activity, enhancer binding
GO:0004871 signal transducer activity
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0006089 lactate metabolic process
GO:0006355 regulation of transcription, DNA-dependent
GO:0006879 cellular iron ion homeostasis
GO:0007165 signal transduction
GO:0008134 transcription factor binding
GO:0009434 microtubule-based flagellum
GO:0010575 positive regulation vascular endothelial growth factor production
GO:0010634 positive regulation of epithelial cell migration
GO:0014850 response to muscle activity
GO:0030154 cell differentiation
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032364 oxygen homeostasis
GO:0032722 positive regulation of chemokine production
GO:0032909 regulation of transforming growth factor-beta2 production
GO:0032963 collagen metabolic process
GO:0035035 histone acetyltransferase binding
GO:0035162 embryonic hemopoiesis
GO:0042541 hemoglobin biosynthetic process
GO:0042593 glucose homeostasis
GO:0042789 mRNA transcription from RNA polymerase II promoter
GO:0042981 regulation of apoptosis
GO:0043193 positive regulation of gene-specific transcription
GO:0043565 sequence-specific DNA binding
GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045821 positive regulation of glycolysis
GO:0045926 negative regulation of growth
GO:0045941 positive regulation of transcription
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046716 muscle maintenance
GO:0046886 positive regulation of hormone biosynthetic process
GO:0046982 protein heterodimerization activity
GO:0050790 regulation of catalytic activity
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051216 cartilage development
GO:0051541 elastin metabolic process
GO:0051879 Hsp90 protein binding

Reference Sequence: NM_001530.2

3958bp CDS 285..2765

Homologous cDNA sequence in the JCRB Genebank

HIF1A (5:5'UTR, C:CDS, 3:3'UTR, N:Unknown)

Human

Chimpanzee