Gene Cluster: ERBB2

Organism: Homo sapiens

Synonymous: HER-2|HER-2/neu|HER2|NEU|NGL|TKR1|c-erb B2

v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)

Map: 17q11.2-q12|17q21.1

GO:0000166 nucleotide binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0004716 receptor signaling protein tyrosine kinase activity
GO:0004888 transmembrane receptor activity
GO:0005006 epidermal growth factor receptor activity
GO:0005509 calcium ion binding
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0006468 protein amino acid phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007422 peripheral nervous system development
GO:0007507 heart development
GO:0007528 neuromuscular junction development
GO:0008045 motor axon guidance
GO:0008283 cell proliferation
GO:0014065 phosphoinositide 3-kinase cascade
GO:0016020 membrane
GO:0016021 integral to membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016740 transferase activity
GO:0019838 growth factor binding
GO:0030879 mammary gland development
GO:0033088 negative regulation of immature T cell proliferation in the thymus
GO:0042060 wound healing
GO:0042552 myelination
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0043235 receptor complex
GO:0043406 positive regulation of MAP kinase activity
GO:0045765 regulation of angiogenesis
GO:0045785 positive regulation of cell adhesion
GO:0046777 protein amino acid autophosphorylation
GO:0046982 protein heterodimerization activity
GO:0048015 phosphoinositide-mediated signaling
GO:0050679 positive regulation of epithelial cell proliferation

Reference Sequence: NM_001005862.1

4816bp CDS 521..4198

Homologous cDNA sequence in the JCRB Genebank

ERBB2 (5:5'UTR, C:CDS, 3:3'UTR, N:Unknown)

Chimpanzee