Gene Cluster: EGFR

Organism: Homo sapiens

Synonymous: ERBB|ERBB1|mENA

epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)

Map: 7p12

GO:0000166 nucleotide binding
GO:0001503 ossification
GO:0003690 double-stranded DNA binding
GO:0004710 MAP/ERK kinase kinase activity
GO:0004888 transmembrane receptor activity
GO:0005006 epidermal growth factor receptor activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0006950 response to stress
GO:0007166 cell surface receptor linked signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0016021 integral to membrane
GO:0016323 basolateral plasma membrane
GO:0016337 cell-cell adhesion
GO:0016740 transferase activity
GO:0030122 AP-2 adaptor complex
GO:0030139 endocytic vesicle
GO:0030235 nitric-oxide synthase regulator activity
GO:0030335 positive regulation of cell migration
GO:0042327 positive regulation of phosphorylation
GO:0042802 identical protein binding
GO:0043006 calcium-dependent phospholipase A2 activation
GO:0043406 positive regulation of MAP kinase activity
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045786 negative regulation of cell cycle
GO:0046777 protein amino acid autophosphorylation
GO:0046982 protein heterodimerization activity
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051015 actin filament binding
GO:0051205 protein insertion into membrane

Reference Sequence: NM_005228.3

5616bp CDS 247..3879

Homologous cDNA sequence in the JCRB Genebank

EGFR (5:5'UTR, C:CDS, 3:3'UTR, N:Unknown)

Chimpanzee