Gene Cluster: CDKN2B

Organism: Homo sapiens

Synonymous: INK4B|MTS2|P15|TP15

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

Link to Entrez Gene

Map: 9p21

GO:0000079 regulation of cyclin-dependent protein kinase activity
GO:0000086 G2/M transition of mitotic cell cycle
GO:0004861 cyclin-dependent protein kinase inhibitor activity
GO:0005515 protein binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0007050 cell cycle arrest
GO:0016301 kinase activity
GO:0019901 protein kinase binding
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0031575 G1/S transition checkpoint
GO:0031668 cellular response to extracellular stimulus
GO:0031670 cellular response to nutrient
GO:0042326 negative regulation of phosphorylation
GO:0045786 negative regulation of cell cycle
GO:0050680 negative regulation of epithelial cell proliferation

Reference Sequence: NM_078487.2

4001bp CDS 361..597

Homologous cDNA sequence in the JCRB Genebank

CDKN2B (5:5'UTR, C:CDS, 3:3'UTR, N:Unknown)

Chimpanzee